Everything about The Beta-globin Co-transcriptional Cleavage Ribozyme totally explained
The
Beta-globin co-transcriptional cleavage ribozyme (CotC ribozyme) is an
RNA enzyme known as a
ribozyme.
Transcription termination of
RNA polymerase II transcripts is proposed to occur by a two stage process. The first stage involves pre-termination cleavage (PTC) of the nascent transcript downstream of the
poly(A) site. This process is also referred to as co-transcriptional cleavage (CoTC). The CoTC process in the human beta-
globin gene has been shown to involve an RNA self-cleaving activity located in the 3' flanking region of the beta-globin gene. The CoTC core is highly conserved in the
3' UTR of other primate beta-globin
genes. Functionally, this CoTC ribozyme resembles the 3' processive, self-cleaving ribozymes described for the protein-encoding genes from the myxomycetes
Didymium iridis and
Physarum polycephalum.
There has been no independent confirmation of these findings.
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